Excitatory amino acid antagonists for acute stroke

Excitatory amino acid antagonists and epilepsy.

I06 (1990) Eur. J. Pharmacol. 189, 381-391 18. Honor&, T., Lauridsen, J. and Krogsgaard-Larsen, P. (1082) J. Neurochem. 38,173-178 19. Murphy, L). E., Snowhill, E. W. and Williams, M. (1087) Neurochem. Kes. 12,775-782 20. Lund, T. M., Madsen, U., Ebert, H.. Jsrgensen, I;. S. and Krogsgaard-Ia-sen, 1’. (1991) Med. Chem. Kes. 1, 130-141 21. Hansen, J. J., Lauridsen, J., Nielsen, E., and Krogsgaar...

Neuroprotective actions of excitatory amino acid receptor antagonists.

Possible therapeutic applications of antagonists of excitatory amino acid neurotransmitters.

The dicarboxylic amino acids, glutamate and aspartate, are excitatory neurotransmitters in many brain regions. Recent animal experiments with analogues of dicarboxylic amino acids that block their excitatory actions, suggest that such selective antagonists could have important therapeutic uses in neurology and psychiatry. The strongest evidence concerns epilepsy and disorders of the motor syste...

Excitatory Amino Acids: Clinical Results with Antagonists

The psychopharmacology of agonists and antagonists of excitatory amino acids is in its infancy relative to the decades of intensive research associated with drugs acting on monoamine neurotransmitter systems. The prototype drug in this class, phencyclidine, and its derivative, ketamine, block the N-methyl-D-aspartate (NMDA) subclass of glutamate receptors with competing with glutamate and witho...

Excitatory Amino Acid Transmission

This book represents the proceedings of a Satellite Symposium to the 30th Congress of the International Union of Physiological Sciences, held in Canada during July of 1986. It is the twenty-fourth volume of the neurology and neurobiology collection. The contents of the book are divided into seven sections, beginning with an overview of the field of excitatory amino acid transmission, and a disc...